Silibinin induces yeast apoptosisSilibinin triggers yeast apoptosis related to mitochondrial Ca influx in Candida albicans.
We explored how silibinin, derived from the milk thistle plant, affects Candida albicans, the yeast that can lead to infections. Our research demonstrated that silibinin treatment significantly increased reactive oxygen species, triggering a cascade of events that caused yeast cell death, or apoptosis. Notably, we observed that mitochondrial calcium overload plays a vital role in this process. While silibinin shows promise for combating yeast infections, our findings highlight the importance of further research to fully understand its potential and mechanisms.
Read More
Silibinin shows antifungal potentialAssessment of silibinin as a potential antifungal agent and investigation of its mechanism of action.
We investigated how silibinin, a compound from milk thistle, impacts yeast infections, specifically targeting Candida albicans. The study revealed that silibinin demonstrates antifungal properties by damaging the fungal plasma membrane and preventing biofilm formation.
After testing various concentrations, we observed significant membrane disruption at doses over 100 µg/mL. This shows that silibinin not only affects the yeast's structure but also hampers its ability to form protective biofilms.
Overall, while promising, more research is needed to fully understand silibinin’s effectiveness as a widespread treatment for yeast infections.
Read More